China (Mainland)
Epothilone B CAS NO.152044-54-7
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- Product Details
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Quick Details
- ProName: Epothilone B
- CasNo: 152044-54-7
- Molecular Formula: C27H41NO6S
- Appearance: White crystalline powder
- Application: API
- DeliveryTime: In stock
- PackAge: aluminous bag
- ProductionCapacity: 10 Kilogram/Year
- Purity: 99%min
- Storage: hading, sealed, dry place.
- Transportation: hading, sealed, dry place.
- LimitNum: 0 Metric Ton
Superiority
|
Product name |
Epothilone B |
CAS: |
152044-54-7 |
|
|
Batch No. |
2013.04.10 |
Report Date |
2013.04.12 |
|
|
Quantity |
10g |
Retest period: |
2015.05.01 |
|
|
Contents of testing |
Specifications |
Results |
||
|
Characters |
Appearance |
White crystalline |
White crystalline |
|
|
Solubility |
Easily soluble in Methanol |
Conform |
||
|
Specific optical rotation |
-35°~-38°(C=0.7%,in methanol) |
-36.4° |
||
|
Identification |
A: Absorption maximum |
Uv max(in methanol):211nm, 249nm |
Conform |
|
|
B:IR |
IR Spectrum of the sample corresponds to that of the reference standard |
Conform |
||
|
C:HPLC |
The reference time of the major peak in the chromatograms corresponds to that in the reference standard. |
Conform |
||
|
Test |
Related compounds |
Epothilone A: Not more than 1.5% |
0.32% |
|
|
Maximum individual impurity: not more than 1.0% |
0.26% |
|||
|
Total impurities:not more than 2.0% |
0.82% |
|||
|
Residual organic solvent |
Methanol: not more than 3000ppm |
1263ppm |
||
|
Ethyl Acetate: not more than 5000ppm |
809ppm |
|||
|
Water |
Not more than 5.0% |
2.6% |
||
|
Reside on ignition |
Not more than 0.2% |
0.1% |
||
|
Purity(HPLC) |
Not less than 98.0% |
99.2% |
||
|
Conclusion: All items comply with the inner quality standard. |
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Details
|
Product name |
Epothilone B |
CAS: |
152044-54-7 |
|
|
Batch No. |
2013.04.10 |
Report Date |
2013.04.12 |
|
|
Quantity |
10g |
Retest period: |
2015.05.01 |
|
|
Contents of testing |
Specifications |
Results |
||
|
Characters |
Appearance |
White crystalline |
White crystalline |
|
|
Solubility |
Easily soluble in Methanol |
Conform |
||
|
Specific optical rotation |
-35°~-38°(C=0.7%,in methanol) |
-36.4° |
||
|
Identification |
A: Absorption maximum |
Uv max(in methanol):211nm, 249nm |
Conform |
|
|
B:IR |
IR Spectrum of the sample corresponds to that of the reference standard |
Conform |
||
|
C:HPLC |
The reference time of the major peak in the chromatograms corresponds to that in the reference standard. |
Conform |
||
|
Test |
Related compounds |
Epothilone A: Not more than 1.5% |
0.32% |
|
|
Maximum individual impurity: not more than 1.0% |
0.26% |
|||
|
Total impurities:not more than 2.0% |
0.82% |
|||
|
Residual organic solvent |
Methanol: not more than 3000ppm |
1263ppm |
||
|
Ethyl Acetate: not more than 5000ppm |
809ppm |
|||
|
Water |
Not more than 5.0% |
2.6% |
||
|
Reside on ignition |
Not more than 0.2% |
0.1% |
||
|
Purity(HPLC) |
Not less than 98.0% |
99.2% |
||
|
Conclusion: All items comply with the inner quality standard. |
||||
A compound isolated from the myxobacterium Sorangium Cellulosum. Similar to paclitaxel,epothilone B induces microtubule polymerization andstabilizes mirotubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Epothilone B may cause complete cell-cycle arrest.